Love the element of surprise in all areas of life, but paricularly in decor. Rooms shouldn't be so serious, but fun and even quirky! Mister Ed brings that element to our home and every single person who comes to our house makes a comment about him, I love it!
Here's some other great examples of quirky chic done well.

Love that print, perfect for a guy's office via decorista

This would be great in a kid's room

Those chairs and that elephant print, so unexpected

Note the family pet in the corner via kristaewart

Bunny rabbit mat!

All other images via mdesign